Publications

Zygotene cilia regulate meiosis, germ cell deleopment and fertility in zebrafish, mice, and humans

ue-Lian Sun, Avishag Mytlis, Sylwia M. Czukiewska, Brigite Cabrita , Mengmeng Ge, Alexandra Sheinberg, Vineet Kumar, Yoel Bogoch, Andrew H. Sinclair , Jingjing Wang, Anna Lokchine, Katie L. Ayers, Sabine Kliesch, Frank Tüttelmann, Julia Wallmeier, Corinna Friedrich, Sylvie Jaillard, Elena J. Tucker, Susana M Chuva de Sousa Lopes, Qing-Feng Wu, Yaniv M. Elkouby & Sudipto Roy;
Research square
https://doi.org/10.21203/rs.3.rs-7733942/v1

The many faces of the bouquet centrosome MTOC in meiosis and germ cell development

Mytlis, A., Levy, K. & Elkouby, Y. M., Apr 2023, In: Current Opinion in Current Opinion in Cell Biology.
81, 102158.

Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium

Mytlis, A., Kumar, V., Qiu, T., Deis, R., Hart, N., Levy, K., Masek, M., Shawahny, A., Ahmad, A., Eitan, H., Nather, F., Adar-Levor, S., Birnbaum, R. Y., Elia, N., Bachmann-Gagescu, R., Roy, S. & Elkouby, Y. M., 17 Jun 2022, In: Science.
376, 6599, eabh3104.

Featured as a Spotlight in:

Olaya and Burgess (2022) Developmental Cell. DOI: 10.1016/j.devcel.2022.06.014
Mahen (2021) preLights.

Morphogenetic ovarian module for oocyte production from germline stem cells

Neta Hart, Johanna B. Kroll, Vineet Kumar, Sylwia M. Czukiewska, Yoel Bogoch, Noga Guler, Karine Levy, Susana M Chuva de Sousa Lopes, Jan Philipp Junker, and Yaniv M. Elkouby;
Research square
https://doi.org/10.21203/rs.3.rs-7325126/v1

Germ cell development: Anchoring and pulling forces shape germline cyst construction

Elkouby, Y. M., 16 Dec 2024, In: Current Opinion in Cell Biology.
34, 24, p. R1228-R1230.

Tools to analyze the organization and formation of the germline cyst in zebrafish oogenesis

Kumar, V. & Elkouby, Y. M., 1 Jul 2023, In: Development.
150, 13, dev201349.

The Balbiani body at a glance

Swastik Kar and Yaniv M. Elkouby;
Journal of Cell Science
https://doi.org/10.1242/jcs.264644

An mTOR-Stat3-Stathmin pathway controls centrosome and microtubule dynamics for oocype polarization

Amal Shawahny, Yoel Bogoch, Neta Hart, Yaniv M. Elkouby;
Current Biology
DOI: 10.1016/j.cub.2025.10.085

An image from this study was selected as BPoD – Biomedical Picture of the Day

The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis

Kar, S., Deis, R., Ahmad, A., Bogoch, Y., Dominitz, A., Shvaizer, G., Sasson, E., Mytlis, A., Ben-Zvi, A. & Elkouby, Y. M., 20 Jan 2025, In: Current Biology.
35, 2, p. 315-332.e7.

A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb

Jamieson-Lucy, A. H., Kobayashi, M., James Aykit, Y., Elkouby, Y. M., Escobar-Aguirre, M., Vejnar, C. E., Giraldez, A. J. & Mullins, M. C., Apr 2022, In: Developmental Biology.
484, p. 1-11 11 p.

Oocyte Polarization Is Coupled to the Chromosomal Bouquet, a Conserved Polarized Nuclear Configuration in Meiosis

Elkouby, Y. M., Jamieson-Lucy, A. & Mullins, M. C., 7 Jan 2016, In: PLoS Biology.
14, 1, e1002335.

Long-term culture of zebrafish developing ovaries as an ex-vivo system for investigation of early oogenesis and ovarian development

A. Shawahny, Y. Bogoch, Y.M. Elkouby, 2026, accepted, STAR protocols.

Stage Specific Transcriptomic Analysis and Database for Zebrafish Oogenesis

Bogoch, Y., Jamieson-Lucy, A., Vejnar, C. E., Levy, K., Giraldez, A. J., Mullins, M. C. & Elkouby, Y. M., 6 Jun 2022, In: Frontiers in Cell and Developmental Biology. 10, 826892.

Live and Time-Lapse Imaging of Early Oogenesis and Meiotic Chromosomal Dynamics in Cultured Juvenile Zebrafish Ovaries

Mytlis, A. & Elkouby, Y. M., 2021, Methods in Molecular Biology.
Humana Press Inc., p. 137-155 19 p. (Methods in Molecular Biology; vol. 2218).

Methods for the analysis of early oogenesis in Zebrafish

Elkouby, Y. M. & Mullins, M. C., 15 Oct 2017, In: Developmental Biology.
430, 2, p. 310-324 15 p.

The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of germ granules

Ahmad, A., Bogoch, Y., Shvaizer, G., Guler, N., Levy, K. & Elkouby, Y. M., 13 Jan 2025, In: PLoS Genetics.
21, 1, e1010868.

In Vitro Storage of Functional Sperm at Room Temperature in Zebrafish and Medaka

Takemoto, K., Nishimura, T., Kawasaki, T., Imai, Y., Levy, K., Hart, N., Olaya, I., Burgess, S. M., Elkouby, Y. M., Tanaka, M. & Sakai, N., 1 Dec 2023, In: Zebrafish.
20, 6, p. 229-235 7 p.

New roles for Wnt and BMP signaling in neural anteroposterior patterning

Polevoy, H., Gutkovich, Y. E., Michaelov, A., Volovik, Y., Elkouby, Y. M. & Frank, D., Jun 2019, In: EMBO Reports.
20, 6, e45842.

All in one – Integrating cell polarity, meiosis, mitosis and mechanical forces in early oocyte differentiation in vertebrates

Elkouby, Y. M., 2017, In: International Journal of Developmental Biology.
61, 3-5, p. 179-193 15 p.
Research output: Contribution to journal › Review article › peer-review

Coordination of cellular differentiation, polarity, mitosis and meiosis – New findings from early vertebrate oogenesis

Elkouby, Y. M. & Mullins, M. C., 15 Oct 2017, In: Developmental Biology.
430, 2, p. 275-287 13 p.

Localization in oogenesis of maternal regulators of embryonic development

Escobar-Aguirre, M., Elkouby, Y. M. & Mullins, M. C., 2017, Advances in Experimental Medicine and Biology.
Springer New York LLC, p. 173-207 35 p. (Advances in Experimental Medicine and Biology; vol. 953).

A hindbrain-repressive Wnt3a/Meis3/Tsh1 circuit promotes neuronal differentiation and coordinates tissue maturation

Elkouby, Y. M., Polevoy, H., Gutkovich, Y. E., Michaelov, A. & Frank, D., 15 Apr 2012, In: Development.
139, 8, p. 1487-1497 11 p.

Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate

Fonar, Y., Gutkovich, Y. E., Root, H., Malyarova, A., Aamar, E., Golubovskaya, V. M., Elias, S., Elkouby, Y. M. & Frank, D., 1 Jul 2011, In: Molecular Biology of the Cell.
22, 13, p. 2409-2421 13 p.

Mesodermal Wnt signaling organizes the neural plate via Meis3

Elkouby, Y. M., Elias, S., Casey, E. S., Blythe, S. A., Tsabar, N., Klein, P. S., Root, H., Liu, K. J. & Frank, D., 1 May 2010, In: Development.
137, 9, p. 1531-1541 11 p.

Wnt/[beta]-catenin signaling in vertebrate posterior neural development

Elkouby, Y. M. & Frank, D., 2010, San Rafael, Calif: Morgan & Claypool.
77 p. (NCBI Bookshelf; vol. # 4).

Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development

Gutkovich, Y. E., Ofir, R., Elkouby, Y. M., Dibner, C., Gefen, A., Elias, S. & Frank, D., 1 Feb 2010, In: Developmental Biology.
338, 1, p. 50-62 13 p.